当前位置:首页 >> 化学 >>

Agomelatine hydrochloride


Product Data Sheet

Product Name: CAS No.: Cat. No.: MWt: Formula: Purity :

Agomelatine hydrochloride 1176316-99-6 HY-17038A 279.76 C15H18ClNO2 >98%

Solubility:

DMSO 49 mg/mL ; Water <1 mg/mL ; Ethanol 49 mg/mL Pathways:Nueronal Signaling; Target:5-HT Receptor Pathways:GPCR/G protein; Target:5-HT Receptor

Mechanisms:

Biological Activity: Agomelatine hydrochloride is a antidepressant antidepressant, which is classified as a norepinephrine-dopamine norepinephrine dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. IC50 value: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b) Target: 5-HT 2c receptor Agomelatine hydrochloride is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways [1]. A total of 42 rats were divided into 7 groups as each composed of 6 rats: (1) intact, (2) 40 mg/kg agomelatine, (3) 140 mg/kg N-acetylcysteine (NAC), (4) 2 g/kg paracetamol, (5) 2 g/kg paracetamol + 140 mg/kg NAC, (6) 2 g/kg paracetamol + 20 m... References: [1]. Chenu F, et al. Role of melatonin, serotonin 2B, and serotonin 2C receptors in modulating the firing activity of rat dopamine neurons. J Psychopharmacol. 2013 Nov 4. [2]. Karakus E, et al. Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage inrats. Hum Exp Toxicol. 2013 Aug;32(8):846-57.

Caution: Not fully tested. For research purposes only Medchemexpress LLC

www.medchemexpress.com
m o c . s s e r p x e m e h c d e m . w w w : b e AW Sm Uo ,c 0 4. 5s 8s 0e r p Jx Ne ,m n e oh t c e cd ne i rm P @ ,o y f an Wi : l ni oa sm n iE k l i W 8 1


相关文章:
更多相关标签: